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However, anavar or primobolan are mild steroids that can produce similar results (in a potentially safer manner), with the effects of long-term HGH-use being relatively unknown. We have recently shown that anavar and primobolan produce similar and potent effects on weight reduction as GH.28,29,30 Therefore, short-term use can be tolerated for short-term weight loss and does not increase risk for chronic health effects. Steroids may exert their antiobesity actions via several different mechanisms including (1) increased insulin sensitivity, (2) increased leptin, and/or (3) augmented fat cell size.31 The mechanisms by which steroids reduce appetite and body weight seem to involve both direct and indirect actions, including increased energy expenditure via increased food and fluid intake, reduced energy expenditure via alterations of energy expenditure via increased caloric expenditure, diminished energy expenditure, reduced metabolic rate via increased activity, decreased fat oxidation, and decreased adiponectin concentrations.32 A number of studies have demonstrated that the effects of steroids on appetite, food intake, food intake satisfaction, and body weight are independent of insulin sensitivity.33–35 In contrast, several independent pathways appear to be involved in the inhibition of food intake and body weight, as well as changes in food intake, resulting in enhanced satiety, satiety-inducing factors (as discussed above), and reduced weight gain. The mechanisms by which steroids affect weight and body size are still unclear, but research is ongoing that may provide insight into the mechanisms. Steroids appear to increase leptin production, as well as leptin receptor binding protein expression in adipocytes.36–38 Increased levels of leptin were observed with anavar.39 Although the mechanisms by which anavar decreases satiety are unknown, there is evidence that anavar reduces ad libitum food intake.40,41 Thus, a reduction of the ability to eat has been observed with steroid use. In conclusion, it has been suggested that there are four basic phases of HGH use prior to weight reduction: the long-term long-term low-dose (LC) HGH period (LTGH), initial LTGH, short-term use (SR), and the short-term use of the current LTGH. We have shown that at least two steroids, either anavar, primobolan, or anastrozole, are significantly safer than either GH or luteinizing hormone-releasing hormone (LH-RH). Although anastrozole may be less physiologically sensitive than anavar, it is an effective tool for weight loss and may produce a greater therapeutic effect in obese adolescents. Anavar, as Related Article: